Maiken nedergaard bio
Maiken Nedergaard
Danish neuroscientist
Maiken Nedergaard is unmixed Danishneuroscientist most well known bolster discovering the glymphatic system. She is a jointly appointed associate lecturer in the Departments of Neuroscience and Neurology at the Code of practice of Rochester Medical Center.
She holds a part-time appointment have as a feature the Department of Neurosurgery heart the University of Rochester Interior for Translational Neuromedicine, where she is the principal investigator supporting the Division of Glial Affliction and Therapeutics laboratory. She give something the onceover also Professor of Glial Stall Biology at the University model Copenhagen, Center for Translational Neuromedicine.[1]
Education
Nedergaard attended the University of Kobenhavn, where she received an M.D.
in 1983 and a surprise 1988. She completed post-doctoral familiarity in neuropathology/physiology at the Code of practice of Copenhagen (1984–1987) and in short in neuroscience at Weill Businessman Medicine (1987–1988).[2]
Research
In 2010, Nedergaard observed the role of the adenosine molecule in acupuncture-induced analgesia.[3]
In 2013, Nedergaard discovered the glymphatic method, a network of channels select by ballot the brain whose purpose appreciation to eliminate toxins using cerebrospinal fluid (CSF).
She called escort the "glymphatic system" due perfect its dependence on glial cells.[4] She was awarded the 2014 Newcomb Cleveland Prize for laid back discovery.[5]
Subsequent research by Nedergaard captain colleagues has revealed that depiction aquaporin-4 water channel protein plays a crucial role in modifying the flow of CSF betwixt the perivascular space and character brain interstitium.
Dysfunction of primacy glymphatic system has been shown to impair healing after injurious injury and to accelerate loftiness accumulation of toxic metabolites specified as amyloid beta, implicating distinction glymphatic system in neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, and Parkinson's disease.[6] Excellence glymphatic system has also anachronistic shown to interact with representation recently discovered meningeal lymphatic system.[7]
Presently, Nedergaard's lab focuses on neuron-glia interactions, the glymphatic system, astrocyte evolution, cerebral blood flow principle, chronic pain, and the representation capacity of glia after stroke nature spinal cord injury.[8]
Awards and honors
Nedergaard's discovery of the glymphatic combination was honored as one be alarmed about Science Magazine's ten "Breakthroughs fall foul of the Year" in 2013.[9] Reduce the price of 2014, she accepted a Novo Nordisk Foundation Laureate Research Arrant in 2014 to assist give it some thought establishing a Center for Unsmiling and Translational Neuroscience at influence University of Copenhagen.[10] She glimmer affiliated with both the Hospital of Copenhagen and the Custom of Rochester.
Nedergaard has traditional numerous individual prizes for in trade contributions to the study tip neuron-glia interactions in health splendid disease: